| Primary Identifier | MGI:4429538 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Notch3*R169C)88Bbb |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Cerebral Ischemic Small Vessel Disease (J:156682) |
| molecularNote | The transgene contains a modified rat BAC RPCI31.78K09 with the rat Notch3 gene carrying the CADASIL-associated mutation R169C. Two lines were created (88 and 92). Line 88 exhibit a 4-fold increase in expression and was selected as the representative line. |
