| Primary Identifier | MGI:97570 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 18671 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including ATP hydrolysis activity; ATPase-coupled intramembrane lipid transporter activity; and xenobiotic transmembrane transporter activity. Involved in export across plasma membrane; lipid transport; and xenobiotic transport across blood-brain barrier. Acts upstream of or within xenobiotic detoxification by transmembrane export across the plasma membrane. Located in apical plasma membrane and intercellular canaliculus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and integumental system. Used to study inflammatory bowel disease 13. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and leukemia (multiple). Orthologous to human ABCB1 (ATP binding cassette subfamily B member 1). PHENOTYPE: Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
