| First Author | Verbon A | Year | 2002 |
| Journal | Clin Exp Immunol | Volume | 130 |
| Issue | 1 | Pages | 32-6 |
| PubMed ID | 12296850 | Mgi Jnum | J:115552 |
| Mgi Id | MGI:3691920 | Doi | 10.1046/j.1365-2249.2002.01952.x |
| Citation | Verbon A, et al. (2002) Mice lacking the multidrug resistance protein 1 have a transiently impaired immune response during tuberculosis. Clin Exp Immunol 130(1):32-6 |
| abstractText | A T helper (Th) 1 immune response is important for host defense against tuberculosis. The multidrug resistance protein (Mrp) 1 is constitutively present at low levels on Th2 lymphocytes, and is expressed on Th1 lymphocytes upon activation. To determine the role of Mrp1 in the pathogenesis of tuberculosis, Mrp1 deficient (-/-) and normal wild type mice were intranasally infected with Mycobacterium tuberculosis. At 2 weeks after infection, Mrp1(-/-) mice had reduced levels of the Th1 cytokine interferon-gamma and an impaired granuloma formation in their lungs. At 5 weeks postinfection, M. tuberculosis outgrowth was enhanced in lungs and livers of Mrp1(-/-) mice. A more prolonged observation of these mice, up to 4 months, revealed no differences in survival or mycobacterial outgrowth. These data suggest that Mrp1 plays an early but dispensable role in the protective immune response to pulmonary tuberculosis. |
