First Author | Pretsch W | Year | 1999 |
Journal | Genet Res | Volume | 73 |
Issue | 1 | Pages | 1-5 |
PubMed ID | 10218442 | Mgi Jnum | J:54306 |
Mgi Id | MGI:1334911 | Doi | 10.1017/s0016672398003590 |
Citation | Pretsch W (1999) Glutathione reductase activity deficiency in homozygous Gr1a1Neu mice does not cause haemolytic anaemia. Genet Res 73(1):1-5 |
abstractText | A glutathione reductase (GR) mutant with approximately 50% residual enzyme activity in blood compared with wild-type was detected amongst offspring of isopropyl methanesulphonate-treated male mice. Homozygous mutants with only 2% residual enzyme activity were recovered in progeny of inter se matings of heterozygotes. Results of linkage studies indicate a mutation at the Gr1 structural locus on chromosome 8. The loss of GR activity was evident both in blood and in other tissue extracts. Erythrocyte and organo-somatic indices did not show differences between wild-types and homozygous mutants, indicating no association between the GR deficiency and haemolytic anaemia in this potential animal model. |