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Publication : Molecular mechanisms of liver development and differentiation.

First Author  Darlington GJ Year  1999
Journal  Curr Opin Cell Biol Volume  11
Issue  6 Pages  678-82
PubMed ID  10600708 Mgi Jnum  J:59809
Mgi Id  MGI:1352179 Doi  10.1016/s0955-0674(99)00035-6
Citation  Darlington GJ (1999) Molecular mechanisms of liver development and differentiation. Curr Opin Cell Biol 11(6):678-82
abstractText  Recent advances in identifying molecular signals that dictate liver development and differentiation have come from analysis of several experimental systems including the developing embryo, cell and tissue culture, knockout mice and transplantation of hepatic precursor cells. Fibroblast growth factors and several families of transcription factors including hepatocyte nuclear factors 1, 3 and 4 and CCAAT/enhancer-binding protein have been shown to be important components of the differentiation process that culminates in the fully functional liver.
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