| First Author | Blomeley C | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 1 | Pages | 29-32 |
| PubMed ID | 29180747 | Mgi Jnum | J:258016 |
| Mgi Id | MGI:6116537 | Doi | 10.1038/s41593-017-0023-y |
| Citation | Blomeley C, et al. (2018) Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals. Nat Neurosci 21(1):29-32 |
| abstractText | Excitation of accumbal D2 cells governs vital actions, including avoidance of learned risks, but the origins of this excitation and roles of D2 cells in innate risk-avoidance are unclear. Hypothalamic neurons producing orexins (also called hypocretins) enhance innate risk-avoidance via poorly understood neurocircuits. We describe a direct orexin-->D2 excitatory circuit and show that D2 cell activity is necessary for orexin-dependent innate risk-avoidance in mice, thus revealing an unsuspected hypothalamus-accumbens interplay in action selection. |
