| Primary Identifier | MGI:1914634 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 67384 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable adenyl-nucleotide exchange factor activity; protein-folding chaperone binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and positive regulation of supramolecular fiber organization. Predicted to be located in plasma membrane. Predicted to be active in cytosol; membrane; and nucleus. Is expressed in foregut; heart ventricle; nose; pituitary gland; and urethra. Orthologous to human BAG4 (BAG cochaperone 4). PHENOTYPE: Homozygous mutant animals may show enhanced cytokine response and increased IL-6 production following TNF challenge. Studies on two different alleles of this gene are not in agreement. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
