| First Author | Engelholm LH | Year | 2003 |
| Journal | J Cell Biol | Volume | 160 |
| Issue | 7 | Pages | 1009-15 |
| PubMed ID | 12668656 | Mgi Jnum | J:82737 |
| Mgi Id | MGI:2654975 | Doi | 10.1083/jcb.200211091 |
| Citation | Engelholm LH, et al. (2003) uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion. J Cell Biol 160(7):1009-15 |
| abstractText | The uptake and lysosomal degradation of collagen by fibroblasts constitute a major pathway in the turnover of connective tissue. However, the molecular mechanisms governing this pathway are poorly understood. Here, we show that the urokinase plasminogen activator receptor-associated protein (uPARAP)/Endo180, a novel mesenchymally expressed member of the macrophage mannose receptor family of endocytic receptors, is a key player in this process. Fibroblasts from mice with a targeted deletion in the uPARAP/Endo180 gene displayed a near to complete abrogation of collagen endocytosis. Furthermore, these cells had diminished initial adhesion to a range of different collagens, as well as impaired migration on fibrillar collagen. These studies identify a central function of uPARAP/Endo180 in cellular collagen interactions. |
