| First Author | Xu J | Year | 2010 |
| Journal | Genesis | Volume | 48 |
| Issue | 6 | Pages | 390-3 |
| PubMed ID | 20533406 | Mgi Jnum | J:163652 |
| Mgi Id | MGI:4822546 | Doi | 10.1002/dvg.20626 |
| Citation | Xu J, et al. (2010) Generation of mice with a conditional null allele of the Jagged2 gene. Genesis 48(6):390-3 |
| abstractText | The Notch signaling pathway is an evolutionarily-conserved intercellular signaling mechanism, and mutations in its components disrupt embryonic development in many organisms and cause inherited diseases in humans. The Jagged2 (Jag2) gene, which encodes a ligand for Notch pathway receptors, is required for craniofacial, limb, and T cell development. Mice homozygous for a Jag2 null allele die at birth from cleft palate, precluding study of Jag2 function in postnatal and adult mice. We have generated a Jag2 conditional null allele by flanking the first two exons of the Jag2 gene with loxP sites. Cre-mediated deletion of the Jag2(flox) allele generates the Jag2(del2) allele, which behaves genetically as a Jag2 null allele. This Jag2 conditional null allele will enable investigation of Jag2 function in a variety of tissue-specific contexts. |
