| First Author | Schrijver G | Year | 1988 |
| Journal | Lab Invest | Volume | 59 |
| Issue | 4 | Pages | 484-91 |
| PubMed ID | 3050274 | Mgi Jnum | J:27624 |
| Mgi Id | MGI:75113 | Citation | Schrijver G, et al. (1988) Antiglomerular basement membrane nephritis in the mouse. Study on the role of complement in the heterologous phase. Lab Invest 59(4):484-91 |
| abstractText | The role of complement was examined in a model of antiglomerular basement membrane nephritis in the mouse, induced by intravenous injection of goat anti-mouse glomerular basement membrane serum, and characterized by early glomerular lesions and a dose-dependent albuminuria. We compared the reaction after injection of the antiserum in complement-normal B10.D2 new mice with that in congenic, congenitally C5-deficient B10.D2 old mice, and in both strains after C3 depletion by treatment with cobra venom factor. The dose-dependent albuminuria was not affected by the absence of complement activation. Also, deficiency of C3 and/or C5 had no inhibitory effect on the histologic glomerular lesions: it did not reduce the influx of polymorphonuclear granulocytes in the glomerular capillary vessels, nor prevented the eventual intravascular coagulation. We conclude that complement-independent mechanisms are involved in the development of the heterologous phase of antiglomerular basement membrane nephritis in the mouse. |
