| First Author | Ventura-Holman T | Year | 1998 |
| Journal | Genomics | Volume | 54 |
| Issue | 2 | Pages | 221-30 |
| PubMed ID | 9828124 | Mgi Jnum | J:51387 |
| Mgi Id | MGI:1316568 | Doi | 10.1006/geno.1998.5569 |
| Citation | Ventura-Holman T, et al. (1998) The murine fem1 gene family: homologs of the Caenorhabditis elegans sex- determination protein FEM-1. Genomics 54(2):221-30 |
| abstractText | The pathway controlling sex determination in the nematode Caenorhabditis elegans is a model for the genetic control of cell-fate determination. We report here the cloning and characterization of a new mouse gene family with homology to FEM-1, a signal-transducing regulator in the C. elegans sex-determination pathway. This gene family consists of two known members, designated Fem1a and Fem1b. The highest degree of homology between the two mouse proteins and the nematode protein is in a domain that encodes seven sequential ANK repeats. The Fem1a gene localizes to chromosome 17 and is highly expressed in adult heart and skeletal muscle. The Fem1b gene localizes to chromosome 9 and is highly expressed in adult testis. Both genes are expressed during embryogenesis. The existence of FEM-1 homologs in the mouse raises the possibility that evolutionary conservation of ancient FEM-1 signaling interactions may play a role in vertebrate cell-fate determination. Copyright 1998 Academic Press. |
