Primary Identifier | MGI:5306232 | Allele Type | Transgenic |
Attribute String | Inserted expressed sequence | Gene | Tg(Alb-FKBP12/CASP8)#Lsu |
Strain of Origin | Not Specified | Is Recombinase | false |
Is Wild Type | false |
molecularNote | This transgene is comprised of the murine albumin reporter driving expression of a fusion protein of the human FK506 binding protein 1A and human caspase 8 from Ser217-Asp479. Ligand induced dimerization results in activation of caspase 8 and ablation of hepatocytes expressing this transgene. |