| Primary Identifier | MGI:1859549 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 547431 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables signaling receptor binding activity. Acts upstream of or within negative regulation of T cell receptor signaling pathway; positive regulation of T cell proliferation; and positive regulation of interleukin-2 production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in intestine and skeletal muscle. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease (multiple); berylliosis; coronary artery disease; and sarcoidosis. Orthologous to human BTNL2 (butyrophilin like 2). PHENOTYPE: Mice homozygous for a null allele show large bowel inflammation, loss of colonic crypt architecture, increase in pro-inflammatory cytokines in colonic tissue and a decrease in gamma-delta T17 cells in the intestinal epithelial lymphocyte population. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
