| First Author | Chow EK | Year | 2006 |
| Journal | J Exp Med | Volume | 203 |
| Issue | 12 | Pages | 2589-602 |
| PubMed ID | 17074929 | Mgi Jnum | J:124623 |
| Mgi Id | MGI:3722041 | Doi | 10.1084/jem.20060929 |
| Citation | Chow EK, et al. (2006) A role for IRF3-dependent RXRalpha repression in hepatotoxicity associated with viral infections. J Exp Med 203(12):2589-602 |
| abstractText | Viral infections and antiviral responses have been linked to several metabolic diseases, including Reye's syndrome, which is aspirin-induced hepatotoxicity in the context of a viral infection. We identify an interferon regulatory factor 3 (IRF3)-dependent but type I interferon-independent pathway that strongly inhibits the expression of retinoid X receptor alpha (RXRalpha) and suppresses the induction of its downstream target genes, including those involved in hepatic detoxification. Activation of IRF3 by viral infection in vivo greatly enhances bile acid- and aspirin-induced hepatotoxicity. Our results provide a critical link between the innate immune response and host metabolism, identifying IRF3-mediated down-regulation of RXRalpha as a molecular mechanism for pathogen-associated metabolic diseases. |
