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Publication : Mapping of the hooded, Gc protein, and albumin gene loci in linkage group VI of the laboratory rat.

First Author  Shumiya S Year  1988
Journal  Biochem Genet Volume  26
Issue  9-10 Pages  585-93
PubMed ID  3242495 Mgi Jnum  J:9714
Mgi Id  MGI:58171 Doi  10.1007/BF02399603
Citation  Shumiya S, et al. (1988) Mapping of the hooded, Gc protein, and albumin gene loci in linkage group VI of the laboratory rat. Biochem Genet 26(9-10):585-93
abstractText  Crosses to determine the position of the three gene loci, h, Gc, and Alb, in the sixth linkage group of the rat used three strains, the TM strain, the ACI-alb analbuminemic congenic strain, and the abh-alb tester strain established by crossing the abh coat color tester strain and analbuminemic rats. Their genotypes were [C/C, h/h, GcB/GcB, Alb/Alb], [C/C, hi/hi, GcA/GcA, alb/alb] and [C/C, h/h, GcA/GcA, alb/alb], respectively. Determination of genotypes was performed by coat color and polyacrylamide gel electrophoresis (PAGE of serum protein for the Gc and albumin genes. The positions of the three gene loci in the VI linkage group were calculated from the recombination values from the phenotypes of progenies. According to this data, the three gene loci were in h-Gc-Alb tandem and the distances were 15.5 +/- 1.0% in h-Gc, 15.8 +/- 1.0% in h-Alb, and 0.32 +/- 0.16% in Gc-Alb. These data confirmed the relationship among the Gc, Alb, and Afp genes in the rat as well as in humans.
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