| First Author | Osawa Y | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 283 |
| Issue | 3 | Pages | 627-33 |
| PubMed ID | 11341770 | Mgi Jnum | J:69453 |
| Mgi Id | MGI:1934684 | Doi | 10.1006/bbrc.2001.4841 |
| Citation | Osawa Y, et al. (2001) Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. Biochem Biophys Res Commun 283(3):627-33 |
| abstractText | Ubiquitin carboxyl-terminal hydrolases (UCHs) are implicated in the proteolytic processing of polymeric ubiquitin. We have isolated a novel mouse gene for ubiquitin carboxyl-terminal hydrolase isozyme L4. The gene named Uchl4 encodes a novel member of the family of ubiquitin carboxyl-terminal hydrolases (UCHs) whose predicted amino acid sequence shows 95% identity to mouse UCH-L3 and 94% identity to human UCH-L3. Genomic structure, chromosome localization, and expression pattern of Uchl3 and Uchl4 were characterized in the mouse. Both Uchl3 and Uchl4 were expressed in various tissues examined; however, expression level was quite lower in Uchl4. While Uchl3 consists of at least 9 exons spanning about 12 kb, Uchl4 was an intronless gene with a size of about 2 kb. By PCR-based analysis with T31 radiation hybrid mapping panel, Uchl3 and Uchl4 were mapped on mouse chromosome 9 and 14, respectively. Copyright 2001 Academic Press. |
