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Protein Coding Gene : Aph1c aph1 homolog C, gamma secretase subunit
Primary Identifier  MGI:1915568 Organism  mouse, laboratory
Chromosome  9 NCBI Gene Number  68318
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable endopeptidase activator activity and protein-macromolecule adaptor activity. Acts upstream of or within several processes, including chemical synaptic transmission; prepulse inhibition; and proteolysis. Part of gamma-secretase complex. Is expressed in brain and genitourinary system. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit).
PHENOTYPE: Homozygous null mice are viable and fertile and do not show any significant aberrations in the brain, kidney, or testis. [provided by MGI curators]
  • synonyms:
  • aph1 homolog C, gamma secretase subunit,
  • RIKEN cDNA 0610008A10 gene,
  • Aph1c,
  • 0610008A10Rik
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1 Involved In Mutations

Trail: ProteinCodingGene

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