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Protein Coding Gene : Hmx3 H6 homeobox 3

Primary Identifier  MGI:107160 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  15373
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0)

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in ear development. Acts upstream of or within several processes, including embryo implantation; maternal process involved in female pregnancy; and neuromuscular process controlling balance. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; branchial arch; female reproductive system; nervous system; and sensory organ. Orthologous to human HMX3 (H6 family homeobox 3).
PHENOTYPE: Homozygotes for targeted null mutations exhibit hyperactivity and circling behavior, and severe vestibular defects. Mutant females are infertile due to failure of implantation. [provided by MGI curators]
  • synonyms:
  • Drosophila NK transcription factor related, gene family 5, locus 1,
  • Nkx5-1,
  • MGD-MRK-35621,
  • Nkx5.1,
  • Hmx3,
  • H6 homeobox 3,
  • MGD-MRK-12895

Features --> Cross References

Genome

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0 Involved In Mutations

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0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

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Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

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1 Driver For