| First Author | Wong M | Year | 1996 |
| Journal | J Mol Endocrinol | Volume | 17 |
| Issue | 2 | Pages | 139-47 |
| PubMed ID | 8938589 | Mgi Jnum | J:37284 |
| Mgi Id | MGI:84686 | Doi | 10.1677/jme.0.0170139 |
| Citation | Wong M, et al. (1996) Cloning and sequence analysis of the human gene encoding steroidogenic factor 1. J Mol Endocrinol 17(2):139-47 |
| abstractText | The orphan nuclear receptor steroidogenic factor 1 (SF-1) plays key roles in endocrine development and function. Initially identified as a positive regulator of the cytochrome P450 steroid hydroxylases, analyses of knockout mice deficient in SF-1 revealed that SF-1 is essential for adrenal and gonadal development, pituitary gonadotropin expression and formation of the ventromedial hypothalamic nucleus. Although more limited in scope, analyses of SF-1 in humans similarly have suggested that SF-1 is important for differentiated function in adrenocortical and gonadotrope adenomas. In the hope of extending our understanding of SF-1 function by identifying possible roles of SF-1 in clinical endocrine disorders, we isolated the FTZ-F1 gene encoding human SF-1 and mapped it to chromosome 9q33. In this report, we characterize the sequence and structural organization of the human cDNA and gene encoding SF-1, providing new insights into comparative aspects of SF-1 structure that will facilitate efforts to study the role of this transcription factor in human endocrine disorders. |
