| Primary Identifier | MGI:1346036 | Organism | mouse, laboratory |
| Chromosome | 9 | NCBI Gene Number | 23988 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein stabilization; and regulation protein catabolic process at postsynapse. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol; nucleus; and postsynapse. Is active in glutamatergic synapse. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). PHENOTYPE: Homozygotes exhibit cell-proliferation abnormalities, including a late-developing reduction in body weight and progressive testicular and retinal atrophies. Mutant females fail to undergo mammary epithelial duct expansion associated with pregnancy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
