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Protein Coding Gene : Grm7 glutamate receptor, metabotropic 7
Primary Identifier  MGI:1351344 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  108073
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables calcium channel regulator activity and voltage-gated calcium channel activity. Involved in chemical synaptic transmission and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including behavioral fear response; learning or memory; and transmission of nerve impulse. Located in presynaptic membrane. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; eye; reproductive system; and spinal cord. Used to study Werdnig-Hoffmann disease. Orthologous to human GRM7 (glutamate metabotropic receptor 7).
PHENOTYPE: Nullizygous mice exhibit seizures and deficits in ejaculation, fear response and conditioned taste aversion. Homozygotes for a knock-in allele show impaired spatial working memory and higher susceptibility to pentylenetetrazol. Homozygotes for a reporter allele show impaired coordination and higher susceptibility to metrazol. [provided by MGI curators]
  • synonyms:
  • Gpr1g,
  • MGD-MRK-10270,
  • mGluR7,
  • E130018M02Rik,
  • MGI:2442018,
  • glutamate receptor, metabotropic 7,
  • mGlu7a receptor,
  • 6330570A01Rik,
  • MGI:2141737,
  • expressed sequence BB176677,
  • BB176677,
  • RIKEN cDNA 6330570A01 gene,
  • MGI:95831,
  • G protein-coupled receptor, family C, group 1, member G,
  • RIKEN cDNA E130018M02 gene,
  • Grm7,
  • MGI:2676918
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