Primary Identifier | MGI:4868765 | Allele Type | Targeted |
Gene | App | Transmission | Germline |
Strain of Origin | 129 | Is Recombinase | false |
Is Wild Type | false |
molecularNote | Exon 16 was replaced with a floxed neo cassette and a modified exon 16 in which a point mutations (TAT to GGA) results in the amino acid substitution of glycine for tyrosine at position 682 (Y682G). Cre-mediated recombination removed the neo cassette. |