| First Author | Neniskyte U | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 17 | Pages | 2952-6 |
| PubMed ID | 24911209 | Mgi Jnum | J:213484 |
| Mgi Id | MGI:5585191 | Doi | 10.1016/j.febslet.2014.05.046 |
| Citation | Neniskyte U, et al. (2014) Tumour necrosis factor alpha-induced neuronal loss is mediated by microglial phagocytosis. FEBS Lett 588(17):2952-6 |
| abstractText | Tumour necrosis factor-alpha (TNF-alpha) is a pro-inflammatory cytokine, expressed in many brain pathologies and associated with neuronal loss. We show here that addition of TNF-alpha to neuronal-glial co-cultures increases microglial proliferation and phagocytosis, and results in neuronal loss that is prevented by eliminating microglia. Blocking microglial phagocytosis by inhibiting phagocytic vitronectin and P2Y6 receptors, or genetically removing opsonin MFG-E8, prevented TNF-alpha induced loss of live neurons. Thus TNF-alpha appears to induce neuronal loss via microglial activation and phagocytosis of neurons, causing neuronal death by phagoptosis. |
