| Primary Identifier | MGI:2445019 | Organism | mouse, laboratory |
| Chromosome | 18 | NCBI Gene Number | 225326 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.4.0) Enables protein kinase activity. Involved in cellular response to glucose starvation; macroautophagy; and synaptic vesicle endocytosis. Acts upstream of or within several processes, including phosphatidylinositol-3-phosphate biosynthetic process; protein localization to phagophore assembly site; and protein phosphorylation. Located in phagocytic vesicle. Part of phosphatidylinositol 3-kinase complex, class III. Is active in GABA-ergic synapse; endosome; and glutamatergic synapse. Is expressed in several structures, including Meckel's cartilage; cardiovascular system; limb; and skeleton. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). PHENOTYPE: Mice homozygous for a null allele display embryonic lethality between implantation and placentation, arrest prior to gastrulation, and show reduced cell proliferation. Mice homozygous for a conditional allele activated in T cells exhibit impaired naive Tcell homeostasis and mitophagy. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
