| Primary Identifier | MGI:109296 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 20775 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable FAD binding activity and squalene monooxygenase activity. Predicted to be involved in several processes, including lipid droplet formation; regulation of cell population proliferation; and sterol metabolic process. Predicted to act upstream of or within lipid metabolic process. Predicted to be located in intracellular membrane-bounded organelle and membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human SQLE (squalene epoxidase). PHENOTYPE: Mice homozygous for a knock-out allele die before E8.5 with a phenotype consistent with that found in mice with mutations affecting cholesterol synthesis. Mice heterozygous the allele exhibit improved Rett syndrome phenotypes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
