| First Author | Kawamura T | Year | 2003 |
| Journal | J Immunol | Volume | 171 |
| Issue | 10 | Pages | 5085-90 |
| PubMed ID | 14607906 | Mgi Jnum | J:119213 |
| Mgi Id | MGI:3701546 | Doi | 10.4049/jimmunol.171.10.5085 |
| Citation | Kawamura T, et al. (2003) Differential roles for IL-15R alpha-chain in NK cell development and Ly-49 induction. J Immunol 171(10):5085-90 |
| abstractText | IL-15Ralpha-deficient (IL-15Ralpha(-/-)) mice lack NK cells. However, when bone marrow (BM) progenitors from IL-15Ralpha(-/-) mice were cultured with IL-7, stem cell factor and flt3 ligand, followed by IL-15, they were able to differentiate into functional NK cells, indicating that IL-15Ralpha is not critical for NK cell development. Whereas NK cells generated in vitro from IL-15Ralpha(-/-) BM progenitors expressed CD94/NKG2, they failed to express Ly-49 receptors. In keeping with this, when IL-15Ralpha(-/-) BM cells were transferred into wild type recipients, they gave rise to NK cells in vivo, but with greatly reduced expression of Ly-49 receptors. Furthermore, the small numbers of NK cells found in IL-15(-/-) as well as IL-15Ralpha(-/-) but not flt3 ligand(-/-) mice expressed much lower levels of Ly-49 receptors than those from wild type mice. These results indicate a novel role for IL-15Ralpha-chain in Ly-49 induction on developing NK cells. |
