Primary Identifier | MGI:1277958 | Organism | mouse, laboratory |
Chromosome | 8 | NCBI Gene Number | 18536 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable molecular adaptor activity. Involved in microtubule anchoring and negative regulation of neurogenesis. Acts upstream of or within several processes, including microtubule anchoring at centrosome; nervous system development; and neuronal stem cell population maintenance. Located in apical part of cell; cytoplasm; and microtubule organizing center. Colocalizes with centrosome. Is expressed in brain; cardiac muscle tissue; and cerebral cortex ventricular layer. Orthologous to human PCM1 (pericentriolar material 1). PHENOTYPE: Haploinsufficient mice show a reduced brain size, behavioral impairment to social stimulus and reduced rearing in the open field test. [provided by MGI curators] |