| First Author | MacLaren DC | Year | 1992 |
| Journal | Genomics | Volume | 14 |
| Issue | 4 | Pages | 852-6 |
| PubMed ID | 1478665 | Mgi Jnum | J:3535 |
| Mgi Id | MGI:52047 | Doi | 10.1016/s0888-7543(05)80104-1 |
| Citation | MacLaren DC, et al. (1992) The L-isoaspartyl/D-aspartyl protein methyltransferase gene (PCMT1) maps to human chromosome 6q22.3-6q24 and the syntenic region of mouse chromosome 10. Genomics 14(4):852-6 |
| abstractText | We have mapped the genes for the human and mouse L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase (EC 2.1.1.77) using cDNA probes. We determined that the human gene is present in chromosome 6 by Southern blot analysis of DNA from a panel of mouse-human somatic cell hybrids. In situ hybridization studies allowed us to confirm this identification and further localize the human gene (PCMT1) to the 6q22.3-6q24 region. By analyzing the presence of an EcoRI polymorphism in DNA from backcrosses of C57BL/6J and Mus spretus strains of mice, we localized the mouse gene (Pcmt-1) to chromosome 10, at a position 8.2 +/- 3.5 cM proximal to the Myb locus. This region of the mouse chromosome is homologous to the human 6q24 region. |
