| First Author | Jółkowska J | Year | 2000 |
| Journal | Leuk Res | Volume | 24 |
| Issue | 7 | Pages | 553-8 |
| PubMed ID | 10867128 | Mgi Jnum | J:63543 |
| Mgi Id | MGI:1861158 | Doi | 10.1016/s0145-2126(00)00031-x |
| Citation | Jolkowska J, et al. (2000) The EVI-1 gene - its role in pathogenesis of human leukemias. Leuk Res 24(7):553-8 |
| abstractText | EVI-1 (ecotropic virus integration site-1) was at first identified as an integration site of the murine leukemia retrovirus in murine myeloid leukemias. It is involved in pathogenesis of mouse and human leukemias. EVI-1 expression may be activated by retroviral insertion or is caused by chromosomal translocations. EVI-1 gene is located on human chromosome 3, spans over 100 kb and contains 12 exons with ten coding exons. EVI-1 gene encodes 1051 amino acids DNA binding protein containing ten zinc finger repeats organized in two domains. The 145 kDa EVI-1 protein is localized in the nucleus. The structure of the EVI-1 protein indicates that it functions as a transcriptional factor of the zinc finger family. The role of this transcription factor in myeloid cell transformation and the target genes of EVI-1 is still unknown. Occurence of a few EVI-1 fusion transcripts was shown. The role of this fusion proteins is still unclear. Mouse and human sequences of the gene show a high degree of homology; 91% in nucleotide sequence and 94% in amino acid sequence. |
