| Primary Identifier | IPR027084 | Type | Family |
| Short Name | Prot_kin_Mps1_fam |
| description | The Mps1 family of protein kinases is a critical regulatorof genetic stability [, ]. In yeast, Mps1 is required for the spindle checkpoint and SPBduplication []. Human Mps1, also known as TTK, is required for proper chromosome alignment on the metaphase plate and for the fidelity of chromosome segregation, and might also have a role at centrosomes[]. It is associated with cell proliferation and involved in mitotic cell cycle checkpoint control [, ]. In late mitosis, Mps1 is ubiquitinated by the APC/C and subsequently degraded []. The catalytic domain of Mps1 is in the C-terminal region, and the N-terminal region includes TPR repeats that promote homodimer formation []. |
