| Primary Identifier | IPR012929 | Type | Domain |
| Short Name | TPR/MLP1 |
| description | This domain is found in a number of proteins, including TPR protein () and yeast myosin-like protein 1 (MLP1, ). These proteins share a number of features; for example, they have coiled-coil regions and are associated with nuclear pores [, , ]. TPR is thought to be a component of nuclear pore complex- attached intranuclear filaments [], and is implicated in nuclear protein import []. Moreover, its N-terminal region is involved in the activation of oncogenic kinases, possibly by mediating the dimerisation of kinase domains or by targeting these kinases to the nuclear pore complex []. Mlp1 acts as a docking platform for for heterogeneous nuclear ribonucleoproteins that are required for mRNA export []. |
