First Author | Nakauchi H | Year | 1985 |
Journal | Proc Natl Acad Sci U S A | Volume | 82 |
Issue | 15 | Pages | 5126-30 |
PubMed ID | 3927298 | Mgi Jnum | J:7962 |
Mgi Id | MGI:56431 | Doi | 10.1073/pnas.82.15.5126 |
Citation | Nakauchi H, et al. (1985) Molecular cloning of Lyt-2, a membrane glycoprotein marking a subset of mouse T lymphocytes: molecular homology to its human counterpart, Leu-2/T8, and to immunoglobulin variable regions. Proc Natl Acad Sci U S A 82(15):5126-30 |
abstractText | The sequence of Lyt-2 cDNA shows that it is a new member of the immunoglobulin super gene family. Analysis of the predicted amino acid sequence indicates that the Lyt-2 polypeptide is synthesized with a 27-amino acid leader, and that the mature protein has an immunoglobulin variable region (Ig V)-related sequence of approximately 100 amino acids, an extracellular spacer of 43, a transmembrane region of 38, and an intracytoplasmic region of 27 amino acids. Lyt-2 and its human analogue Leu-2 are 56% homologous; analysis indicates that the Ig V-related domains of the two molecules have evolved away from each other faster than the carboxyl-terminal half of the proteins. |