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Publication : Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases.

First Author  Sakakibara Y Year  1998
Journal  Biochem Biophys Res Commun Volume  247
Issue  3 Pages  681-6
PubMed ID  9647753 Mgi Jnum  J:48327
Mgi Id  MGI:1267177 Doi  10.1006/bbrc.1998.8872
Citation  Sakakibara Y, et al. (1998) Molecular cloning, expression, and functional characterization of novel mouse sulfotransferases. Biochem Biophys Res Commun 247(3):681-6
abstractText  Nucleotide sequences of two mouse cDNAs encoding new sulfotransferase enzymes were determined. Analysis of the deduced amino acid sequences revealed that one represents a novel member of the phenol sulfotransferase family and the other is highly homologous to human SULT2B1 hydroxysteroid sulfotransferases. The recombinant enzymes, transiently expressed in COS-7 cells, were characterized with respect to their substrate specificity using a variety of substrates for different types of sulfotransferases. The tissue-specific expression of these two new mouse sulfotransferases was examined by Northern blot analysis.
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