| First Author | Choi YR | Year | 2018 |
| Journal | Cell Rep | Volume | 22 |
| Issue | 1 | Pages | 136-148 |
| PubMed ID | 29298416 | Mgi Jnum | J:272465 |
| Mgi Id | MGI:6280306 | Doi | 10.1016/j.celrep.2017.12.009 |
| Citation | Choi YR, et al. (2018) Prion-like Propagation of alpha-Synuclein Is Regulated by the FcgammaRIIB-SHP-1/2 Signaling Pathway in Neurons. Cell Rep 22(1):136-148 |
| abstractText | Recent evidence of prion-like propagation of alpha-synuclein (alpha-syn) into neighboring neurons set up a paradigm to elucidate the mechanism of progression of Parkinson's disease (PD) and to develop therapeutic strategies. Here, we show that FcgammaRIIB expressed in neurons functions as a receptor for alpha-syn fibrils and mediates cell-to-cell transmission of alpha-syn. SHP-1 and 2 are activated downstream by alpha-syn fibrils through FcgammaRIIB and play an important role in cell-to-cell transmission of alpha-syn. Also, taking advantage of a co-culture system, we show that cell-to-cell transmission of alpha-syn induces intracellular Lewy body-like inclusion body formation and that the FcgammaRIIB/SHP-1/2 signaling pathway is involved in it. Therefore, the FcgammaRIIB-SHP-1/-2 signaling pathway may be a therapeutic target for the progression of PD. The in vitro system is an efficient tool for further high-throughput screening that can be used for developing a therapeutic intervention in PD. |
