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Publication : New insight puts CRAF in sight as a therapeutic target.

First Author  Rebocho AP Year  2011
Journal  Cancer Discov Volume  1
Issue  2 Pages  98-9
PubMed ID  22318779 Mgi Jnum  J:189130
Mgi Id  MGI:5444375 Doi  10.1158/2159-8290.CD-11-0118
Citation  Rebocho AP, et al. (2011) New insight puts CRAF in sight as a therapeutic target. Cancer Discov 1(2):98-9
abstractText  By selectively depleting components of the RAF-MEK-ERK pathway in transgenic mice, it is now shown in 2 studies that CRAF is critical for signaling to MEK downstream of oncogenic Kras and that BRAF is not required.
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