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Protein Domain : Transcriptional and immune response regulator

Primary Identifier  IPR039580 Type  Family
Short Name  Tcim
description  Transcriptional and immune response regulator (Tcim; also known as C8orf4 or TC1) is a regulator implicated in cancer and inflammation []. It is highly expressed in several tumours and implicated in tumorigenesis. It plays a role in the mitogen-activated MAPK2/3 signaling pathway, and positively regulates G1-to-S-phase transition of the cell cycle []. It negatively regulates the self-renewal of liver cancer stem cells via suppression of NOTCH2 signalling [].
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