| First Author | Anton E | Year | 1993 |
| Journal | J Appl Toxicol | Volume | 13 |
| Issue | 6 | Pages | 423-7 |
| PubMed ID | 8288846 | Mgi Jnum | J:21584 |
| Mgi Id | MGI:66519 | Doi | 10.1002/jat.2550130609 |
| Citation | Anton E (1993) Differential sensitivity of DBA/2 and C57BL/6 mice to cyclophosphamide. J Appl Toxicol 13(6):423-7 |
| abstractText | Early and delayed toxicity of a single dose of 300 mg kg-1 cyclophosphamide (CP) was investigated in male DBA/2 and C57BL/6 mice. Early toxicity (up to 30 days after CP administration) resulted in 36.6% lethality in DBA/2 and no mortality in C57BL/6 mice. Delayed toxicity (after 30 days) occurred primarily in DBA/2 mice, resulting in a survival of 3% in DBA/2 and 93% in C57BL/6 mice on day 125 after CP administration. Early modifications brought about by CP in erythrocytes and leucocytes, and spleen and liver indexes (mg organ g-1 body wt.) were rather similar in DBA/2 and C57BL/6 strains. However, CP treatment caused a profound cell depletion in DBA/2 bone marrow owing, in part, to the fact that the number of cells in bone marrow of normal DBA/2 mice was much lower than that in normal C57BL/6 mice. Furthermore, the thymus index (mg organ g-1 body wt.) decreased sooner in DBA/2 than in C57BL/6 animals and no sign of recovery was evident in the former even after 10 days, whereas recovery in the latter started on day 5 after injection. Differential sensitivity of DBA/2 and C57BL/6 strains to CP could be due to differences in activation and/or inactivation of the drug, or to the increased effect of CP on DBA/2 bone marrow resulting in damage to pre-T cells that normally participate in thymus recovery. |
