| First Author | Juriloff DM | Year | 1995 |
| Journal | Mamm Genome | Volume | 6 |
| Issue | 2 | Pages | 63-9 |
| PubMed ID | 7767007 | Mgi Jnum | J:22810 |
| Mgi Id | MGI:70698 | Doi | 10.1007/BF00303246 |
| Citation | Juriloff DM, et al. (1995) The major locus for multifactorial nonsyndromic cleft lip maps to mouse chromosome 11. Mamm Genome 6(2):63-9 |
| abstractText | Cleft lip with or without cleft palate, CL(P), a common human birth defect, has a genetically complex etiology. An animal model with a similarly complex genetic basis is established in the A/WySn mouse strain, in which 20% of newborns have CL(P). Using a newly created congenic strain, AEJ.A, and SSLP markers, we have mapped a major CL(P)-causing gene derived from the A/WySn strain. This locus, here named clf1 (cleft lip) maps to Chromosome (Chr) 11 to a region having linkage homology with human 17q21-24, supporting reports of association of human CL(P) with the retinoic acid receptor alpha (RARA) locus. |
