| First Author | Seth P | Year | 1997 |
| Journal | Biochem Biophys Res Commun | Volume | 241 |
| Issue | 2 | Pages | 535-40 |
| PubMed ID | 9425306 | Mgi Jnum | J:44925 |
| Mgi Id | MGI:1101471 | Doi | 10.1006/bbrc.1997.7840 |
| Citation | Seth P, et al. (1997) Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun 241(2):535-40 |
| abstractText | We have isolated a mouse cDNA which codes for a functional type 1 sigma receptor. The functional identity of the cDNA was established by expressing the cDNA in mammalian cells and measuring the cDNA-induced binding of haloperidol. Using this cDNA as the probe, we have isolated a murine genomic clone which contains the type 1 sigma receptor gene in its entirety. We have sequenced the gene completely, deduced the exon-intron organization and analyzed the promoter region sequence for transcription factor binding sites. The gene (approximately 7 kbp) is TATA-less but contains CCAATC and GC boxes immediately upstream of the transcription start site. The gene consists of 4 exons and 3 introns. The 5'-flanking region contains putative binding sites for AP-1, AP-2, GATA-1 and steroid receptors. |
