| First Author | Takeuchi S | Year | 2009 |
| Journal | FEBS Lett | Volume | 583 |
| Issue | 8 | Pages | 1237-42 |
| PubMed ID | 19306875 | Mgi Jnum | J:147984 |
| Mgi Id | MGI:3843120 | Doi | 10.1016/j.febslet.2009.03.032 |
| Citation | Takeuchi S, et al. (2009) Beta2-chimaerin binds to EphA receptors and regulates cell migration. FEBS Lett 583(8):1237-42 |
| abstractText | Ephrins and Eph receptors have key roles in regulation of cell migration during development. We found that the RacGAP beta2-chimaerin (chimerin) bound to EphA2 and EphA4 and inactivated Rac1 in response to ephrinA1 stimulation. EphA4 bound to beta2-chimaerin through its kinase domain and promoted binding of Rac1 to beta2-chimaerin. In addition, knockdown of endogenous beta2-chimaerin blocked ephrinA1-induced suppression of cell migration. These results suggest that beta2-chimaerin is activated by EphA receptors and mediates the EphA receptor-dependent regulation of cell migration. |
