| First Author | Boothe AD | Year | 1977 |
| Journal | Fed Proc | Volume | 36 |
| Pages | 1158 (Abstr.) | Mgi Jnum | J:83825 |
| Mgi Id | MGI:2663698 | Citation | Boothe AD, et al. (1977) Tissue cholesterol storage disorder in BALB/c mice: histologic findings. Fed Proc 36:1158 (Abstr.) |
| abstractText | Full text of Abstract. 4692. TISSUE CHOLESTEROL STORAGE DISORDER IN BALB/c MICE: HISTOLOGIC FINDINGS. A.D. Boothe*, C. Bhuvaneswaran*, M.D. Morris, and J.E. Barry*, University of Arknsas for Medical Sciences, Little Rock, AR 72201 and The National Center for Toxicological Research, Jefferson AR. 72079. BALB/c mice with a cholesterol storage disease have been studied by light and electron microscopy. Affected animals first developed extensor spasticity of the forelimbs, later incoordination of locomotion, and gradual weight loss. Detection of affected animals was made anywhere between 34 and 70 days of age and death occurred between 62 and 82 days. Histopathology revealed many large foamy reticuloendothelial cells in the liver, spleen, thymus gland, lymph nodes, lung and bone marrow. There was a loss of the Purkinje cells of the cerebellum and vacuolation of the cytoplasm of large neurons in nuclei of brain stem and ventral horns of the spinal cord. In the terminal stages of the disease, the percentage of organ to body weight was increased in the liver, spleen, and brain of the affected mice in contrast to their normal littermates. On the other hand, the thymus gland was decreased. Approximately 23% of the living progeny from known carrier parents became affected with a distribution of 20% of all males and 25% of all females. Distribution of affected progeny from different parents varied between 15 and 34%. All clinically affected mice were histopathologically confirmed as having storage disease. |
