| First Author | Srinivasan A | Year | 2007 |
| Journal | J Immunol | Volume | 178 |
| Issue | 10 | Pages | 6342-9 |
| PubMed ID | 17475863 | Mgi Jnum | J:146116 |
| Mgi Id | MGI:3836705 | Doi | 10.4049/jimmunol.178.10.6342 |
| Citation | Srinivasan A, et al. (2007) Innate immune activation of CD4 T cells in salmonella-infected mice is dependent on IL-18. J Immunol 178(10):6342-9 |
| abstractText | Production of IFN-gamma by CD4 T cells is generally thought to be mediated by TCR triggering, however, Ag-nonspecific activation of effector CD8 T cells has been reported in infection models. In this study, we demonstrate that Ag-experienced CD4 T cells in the spleen of Salmonella-infected mice acquire the capacity to rapidly secrete IFN-gamma in response to stimulation with bacterial lysate or LPS. This innate responsiveness of T cells was transient and most apparent during, and immediately following, active Salmonella infection. Furthermore, innate T cell production of IFN-gamma in response to bacterial lysate or LPS was Ag independent and could be induced in Listeria-infected mice and in the absence of MHC class II expression. IL-18 was required for maximal innate responsiveness of CD4 T cells in Salmonella-infected mice and for optimal bacterial clearance in vivo. These data demonstrate that CD4 T cells acquire the capacity to respond to innate stimuli during active bacterial infection, a process that may contribute significantly to amplifying effector responses in vivo. |
