| Primary Identifier | MGI:1338068 | Organism | mouse, laboratory |
| Chromosome | 17 | NCBI Gene Number | 18607 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Enables 3-phosphoinositide-dependent protein kinase activity. Involved in several processes, including negative regulation of cardiac muscle cell apoptotic process; transmembrane receptor protein tyrosine kinase signaling pathway; and type B pancreatic cell development. Acts upstream of or within hyperosmotic response. Located in cytoplasmic vesicle and postsynaptic density. Is expressed in several structures, including central nervous system; early conceptus; gonad; hemolymphoid system gland; and retina. Human ortholog(s) of this gene implicated in prostate cancer. Orthologous to several human genes including PDPK1 (3-phosphoinositide dependent protein kinase 1). PHENOTYPE: Homozygous mutant mice exhibit embryogenesis defects, impaired forebrain development, and die by mid gestation. Cardiac muscle-specific conditional mutants exhibit thin ventricular walls and die of heart failure. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
