| Type | MGI:General | Description | skinned cardiomyocytes from homozygotes exhibit faster loaded shortening velocities, greater power output, and increased force redevelopment rates, due to increased crossbridge interaction kinetics resulting from absence of myosin head constraints peak normalized power output is increased by 26% in mutant cardiomyocytes during maximal Ca2+ activations peak power output is increased to an even greater extent (46%) during half-maximal Ca2+ activations the rate constant of force redevelopment (ktr) is unaltered during maximal Ca2+ activations; however, ktr at half-maximal Ca2+ activation is significantly greater in mutant cardiomyocytes relative to wild-type |
