| First Author | Popovich IG | Year | 2003 |
| Journal | Bull Exp Biol Med | Volume | 136 |
| Issue | 6 | Pages | 595-8 |
| PubMed ID | 15500082 | Mgi Jnum | J:94109 |
| Mgi Id | MGI:3511102 | Doi | 10.1023/b:bebm.0000020214.47787.12 |
| Citation | Popovich IG, et al. (2003) Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. Bull Exp Biol Med 136(6):595-8 |
| abstractText | Treatment of female SAMP-1 mice with Neuronol (drug containing succinic acid) given with drinking water starting from the age of 2 months during the whole life prolonged the lifespan and markedly reduced mortality of animals aged 1.5-2 years. Neuronol inhibited the development of spontaneous tumors, primarily lymphomas, and significantly prolonged lifespan in mice with tumors. Long-term treatment with Neuronol had no pathological side effects. Our experiments demonstrated geroprotective and anticarcinogenic activity of Neuronol and safety of its long-term use. |
