| First Author | Bachmann MF | Year | 1993 |
| Journal | Science | Volume | 262 |
| Issue | 5138 | Pages | 1448-51 |
| PubMed ID | 8248784 | Mgi Jnum | J:127574 |
| Mgi Id | MGI:3763947 | Doi | 10.1126/science.8248784 |
| Citation | Bachmann MF, et al. (1993) The influence of antigen organization on B cell responsiveness. Science 262(5138):1448-51 |
| abstractText | The influence of antigen epitope density and order on B cell induction and antibody production was assessed with the glycoprotein of vesicular stomatitis virus serotype Indiana [VSV-G (IND)]. VSV-G (IND) can be found in a highly repetitive form the envelope of VSV-IND and in a poorly organized form on the surface of infected cells. In VSV-G (IND) transgenic mice, B cells were unresponsive to the poorly organized VSV-G (IND) present as self antigen but responded promptly to the same antigen presented in the highly organized form. Thus, antigen organization influences B cell tolerance. |
