| Primary Identifier | MGI:1341217 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 22200 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Enables NEDD8 activating enzyme activity. Acts upstream of or within endomitotic cell cycle and regulation of cell cycle. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in embryo; eye; limb; and limb mesenchyme. Orthologous to human UBA3 (ubiquitin like modifier activating enzyme 3). PHENOTYPE: Homozygous null mutants die at the peri-implantation stage. Mutants exhibit selective apoptosis of the inner cell mass but not of trophoblastic cells. Moreover, the trophoblastic cells fail to enter the S phase of the endoreduplication cycle. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
