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Allele : Asxl1<tm1.1Hft> ASXL transcriptional regulator 1; targeted mutation 1.1, Hwei-Fang Tien
Primary Identifier  MGI:6306114 Allele Type  Targeted
Attribute String  Not Specified Gene  Asxl1
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette was inserted upstream of a modified exon 13 in which insertion of a G bp results in a G to W nonsense mutation and frame shift truncation following 12 aberrant amino acids. This mutation mimics one identified in patients with acute myeloid leukemia. Cre-mediation removed the selection cassette.
  • mutations:
  • Insertion,
  • Single point mutation
  • synonyms:
  • Asxl1<tm>,
  • Asxl1<tm>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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0 Driven By

3 Publication categories

Trail: Allele




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