Primary Identifier | IPR037927 | Type | Family |
Short Name | KMT2A |
description | Histone-lysine N-methyltransferase 2A (KMT2A; ) is the catalytic subunit of the MLL1/MLL complex, mediating methylation of 'Lys-4' of histone H3 (H3K4me), a specific tag for epigenetic transcriptional activation []. KMT2A is processed by the threonine endopeptidase taspase, releasingproducts N320 and C180 []. KMT2A contains a CxxC (x for any residue) zinc finger domain, three plant homeodomain (PHD) fingers, a Bromodomain domain, an extended PHD (ePHD) finger, Cys2HisCys5HisCys2His, two FY (phenylalanine tyrosine)-rich domains, and a SET (Suppressor of variegation, Enhancer of zeste, Trithorax) domain. |