| First Author | Anderson AC | Year | 2007 |
| Journal | Science | Volume | 318 |
| Issue | 5853 | Pages | 1141-3 |
| PubMed ID | 18006747 | Mgi Jnum | J:127314 |
| Mgi Id | MGI:3763563 | Doi | 10.1126/science.1148536 |
| Citation | Anderson AC, et al. (2007) Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318(5853):1141-3 |
| abstractText | CD4+ T helper 1 (TH1) cells are important mediators of inflammation and are regulated by numerous pathways, including the negative immune receptor Tim-3. We found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors. Moreover, an antibody agonist of Tim-3 acted as an adjuvant during induced immune responses, and Tim-3 ligation induced distinct signaling events in T cells and dendritic cells; the latter finding could explain the apparent divergent functions of Tim-3 in these cell types. Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions. |
